SCHOOL OF MEDICINE  |  PITT HOME  |  FIND PEOPLE  |  FIND A DOCTOR AT UPMC

Department of Medicine

Department of Medicine

  Division of Endocrinology and Metabolism

[Return To Index page]
photo Erin E. Kershaw, MD

Chief, Division of Endocrinology and Metabolism

Associate Professor of Medicine

Email: kershawe@pitt.edu

Phone: 412-648-9043

Contact
Office: E1140 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
 
Phone: 412-648-9043
Fax: 412-648-3290
E-mail: kershawe@pitt.edu
Administrative Assistant:
Kelli Lange
Address: E1140 Biomedical Science Tower
200 Lothrop Street
Pittsburgh, PA 15213
Email: kal134@pitt.edu
Phone: 412-648-8630
Fax: 412-648-3290
Education and Training
Education
BA, Cornell University College of Arts and Sciences, 1991
MD, Weill Cornell Medical College of Cornell University, 1997
Training
Intern, Department of Medicine, New York Presbyterian Hospital- Cornell Campus, 1998
Resident, Department of Medicine, New York Presbyterian Hospital- Cornell Campus, 2000
Fellow, Division of Endocrinology, Department of Medicine, Beth Israel Deaconess, 2003
Instructor, Division of Endocrinology, Department of Medicine, Beth Israel Deaconess, 2008
Research Interest
Dr. Kershaw's academic mission is to forward the understanding and treatment of obesity and related metabolic disorders by combining basic and translational research with clinical expertise. Obesity is a global public health threat that is frequently associated with additional metabolic abnormalities including insulin resistance, glucose intolerance, dyslipidemia, and hypertension (the metabolic syndrome). Together these abnormalities contribute to diseases affecting virtually every organ system. Dr. Kershaw's laboratory focuses on defining the mechanisms by which intracellular lipid metabolism (synthesis, storage, hydrolysis, and oxidation) contributes to obesity and associated metabolic disorders. Most recently, Dr. Kershaw's research efforts have focused on pathways of triacylglycerol hydrolysis (lipolysis) – arguably one of the most fundamental processes in metabolism. Dr. Kershaw is working to define how tissue-specific triacylglycerol hydrolysis contributes to metabolic phenotypes, not only in the metabolic syndrome, but also in variety of other diseases ranging from infertility to cancer. Another major focus of her laboratory is to identify and characterize additional proteins and pathways that contribute to metabolic disease. These efforts fall into two main areas: 1) characterizing novel adipocyte-secreted factors (adipokines) and their relationship to metabolic disease in humans, and 2) characterizing novel genes/loci linked to metabolic disease in humans. Dr. Kershaw's laboratory uses a combination of molecular, cellular, physiological, and translational approaches. The ultimate goal is to develop more effective strategies for prevention and treatment of obesity and associated metabolic disorders.
Clinical Interest
Dr. Kershaw's clinical interests focus on disorders of "fat," including the following core areas: 1) obesity, insulin resistance, diabetes, and metabolic syndrome, 2) pre- and post-operative care for bariatric surgery patients, 3) lipodystrophies, lipomatoses, and rare adipose tissue disorders, and 4) lipid metabolism and dyslipidemias. Dr. Kershaw is board certified in 1) Endocrinology, Diabetes, and Metabolism by the American Board of Internal Medicine (ABIM), 2) Obesity Medicine by the American Board of Obesity medicine (ABOM), and Clinical Lipidology by the American Board of Clinical Lipidology (ABCL).
Educational Interest
Dr. Kershaw's educational mission is to facilitate the career development of trainees in the field of Endocrinology and Metabolism with an emphasis on obesity and its complications. She accomplishes this mission through a combination of didactic coursework, hands-on training, and mentoring. In this way, Dr. Kershaw, has contributed to the scientific and academic development of several trainees ranging from undergraduate students to trainees at the T32 and K level. Several of her prior trainees have subsequently secured independent tenure-track research positions, academic positions, and/or positions in pharmaceutical companies. Dr. Kershaw has held several research training leadership positions including serving as the Associated Program Director for Research for the Clinical Adult Endocrine Fellowship Program, as an oversight committee member for the T32 Training Program in Endocrinology, and as a member of the Physician Scientist Training Program Steering Committee at t he University of Pittsburgh.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004; 89(6): 2548-56.
Kershaw EE, Morton NM, Dhillon H, Ramage L, Seckl JR, Flier JS. Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity. Diabetes. 2005; 54(4): 1023-31.
Kershaw EE, Hamm JK, Verhagen LA, Peroni O, Katic M, Flier JS. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes. 2006; 55(1): 148-57.
Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS. PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab. 2007; 293(6): 1736-45.
Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008; 283(21): 14230-41.
Basantani, M.K., Sitnick, M.T., Cai, L., Brenner, D.S., Gardner, N.P., Li, J.Z., Schoiswohl, G., Yang, K., Kumari, M., Gross, R.W., Zechner, R., Kershaw, E.E. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. Journal of Lipid Research. 2011; 52(2): 318-29.
Pulinilkunnil, T., Kienesberger, P.C., Nagendran, J., Waller, T.J., Young, M.E., Kershaw, E.E., Korbutt, G., Haemmerle, G., Zechner, R., Dyck, J.R. Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy. Diabetes. 2013; 62(5): 1464-77.
Mottillo, E.P., Balasubramanian, P., Lee, Y.H., Weng, C., Kershaw, E.E., Granneman, J.G. Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic ß3-adrenergic receptor activation. Journal of Lipid Research. 2014; 55(11): 2276-86.
Schoiswohl, G., Stefanovic-Racic, M., Menke, M.N., Wills, R.C., Surlow, B.A., Basantani, M.K., Sitnick, M.T., Cai, L., Yazbeck, C.F., Stolz, D.B., Pulinilkunnil, T., O'Doherty, R.M., Kershaw, E.E. Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice. Endocrinology. 2015; 156(10): 3610-24.
Rachakonda, V.P., Reeves, V.L., Aljammal, J., Wills, R.C., Trybula, J.S., DeLany, J.P., Kienesberger, P.C., Kershaw, E.E. Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity. Obesity. 2015; 23(5): 965-72.
Sponsored Research/Activities
Title: Adipocyte Lipolysis, Adipose Tissue Function, and Lipodystrophy
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R56 DK090166
Start Year: 2016
End Year: 2017
Title: Dendritic Cells and Obesity
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK102839
Start Year: 2015
End Year: 2019
Title: Adipose Triglyceride Lipase (ATGL) in Lipotoxicity and the Metabolic Syndrome
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK090166
Start Year: 2011
End Year: 2016
Title: Contribution of the Patatin-Like Phospholipase Domain Containing Proteins (PNPLAs), Adipose Triglyceride Lipase (ATGL) and Adiponurtin, to Lipotoxicity and the Metabolic Syndrome
Role: Co-Investigator
Funding Agency: Hughes Medical Institute
Start Year: 2009
End Year: 2014
Notable Achievements
Howard Hughes Medical Institute (HHMI), Physician-Scientist Early Career Award, 2009
Endocrine Fellows Foundation, Endocrine Fellow Research Award, 2002
The Endocrine Society, Honorary Membership Award for Endocrine Research and Education, 1997
Cornell University Medical College, Janet M. Glasgow Memorial Achievement Award, 1997
Cornell University Medical College, Medical Doctorate with Honors in Research, 1997
Cornell University Medical College, Alpha Omega Alpha Medical Honor Society, 1996
Howard Hughes Medical Institute (HHMI), Award for Continuation of Medical Studies (year 2), 1996
Howard Hughes Medical Institute (HHMI), Award for Continuation of Medical Studies (Year 1), 1995
Cornell University Medical College, Dean's Research Award, 1995
Cornell University Medical College, Dr. Harold Lamport Biomedical Research Award, 1994