SCHOOL OF MEDICINE  |  PITT HOME  |  FIND PEOPLE  |  FIND A DOCTOR AT UPMC

Department of Medicine

Department of Medicine

  

RESEARCH




Division
Research Pages


Research

The University of Pittsburgh Department of Medicine is a formidable leader in cutting-edge research. Our basic scientists, clinical researchers, and clinicians work daily to make research discoveries that will positively impact the world’s healthcare.

Our numbers:

Our scientists, physician-scientists, and clinicians do the advanced research that is changing people’s lives—and furthering our understanding of science. The papers they publish in high-impact journals … the grants and training awards they receive, including five new T32s in fiscal year 2015-16 … are all reflections of our investigators’ skill, dedication, and commitment.


  • Latest High-Impact Publications
  • Latest Grants, $1 Million and Above
   

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy.
Pasi KJ, Rangarajan S, Georgiev P, Mant T, Creagh MD, Lissitchkov T, Bevan D, Austin S, Hay CR, Hegemann I, Kazmi R, Chowdary P, Gercheva-Kyuchukova L, Mamonov V, Timofeeva M, Soh CH, Garg P, Vaishnaw A, Akinc A, Sørensen B, Ragni MV.
N Engl J Med. 2017;377:819-28 August 31, 2017

 

Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias.
Gauthier M, Chakraborty K, Oriss TB, Raundhal M, Das S, Chen J, Huff R, Sinha A, Fajt M, Ray P, Wenzel SE, Ray A.
JCI Insight. 2017 Jul 6;2(13). [Epub ahead of print] JCI Insight. 2017

 

Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity.
Matte-Martone C, Liu J, Zhou M, Chikina M, Green DR, Harty JT, Shlomchik WD.
J Clin Invest. 2017 Jun 30;127(7):2765-2776.
PMID: 28604385

 

A Hippo in the Fox(p3) house.
McGeachy MJ.
Nat Immunol. 2017 Jun 20;18(7):709-711.
PMID: 28632715

 

Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation.
Wei J, Song S, Bowser RK, Khoo A, Zhang L, Jacko AM, Zhao Y, Zhao J.
Sci Signal. 2017 Jun 13;10(483).
PMID: 28611184

 

Accelerated Approval and Expensive Drugs - A Challenging Combination
Gellad WF, Kesselheim AS.
N Engl J Med. 2017 May 25;376(21):2001-2004.
PMID:28538133

 

IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice. 
Oriss TB, Raundhal M, Morse C, Huff RE, Das S, Hannum R, Gauthier MC, Scholl KL, Chakraborty K, Nouraie SM, Wenzel SE, Ray P, Ray A.
JCI Insight. 2017 May 18;2(10): e91019

 

Outcomes of acute leukemia patientstransplanted with naive T cell-depleted stem cell grafts.
Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA,Sommermeyer F, Riddell SR, Shlomchik WD.
J Clin Invest. 2017 Apr 27:JCO2016694935.
PMID: 26053664 

 

   

PI: Iain Scott, PhD, Division of Cardiology | Bio
Agency: NHLBI
Title: Regulation of Fuel Utilization by Lysine Acetylation in the Failing Heart
Project timeline: 9/1/2017-8/31/2021
Direct Costs: $1,240,388
Indirect Costs: $508,827

 

PI: Manisha Jhamb, MBBS, Division of Renal Electrolyte | Bio
Agency: NIDDK
Title: Technology Assisted Stepped Collaborative Care Intervention (TASCCI) to Improve Patient-centered Outcomes in Hemodialysis Patients
Project timeline: 9/1/2017-8/31/2021
Direct Costs: $2,005,853
Indirect Costs: $642,366

 

PI: Sruti Shiva, PhD, Vascular Medicine Institute | Bio
Agency: NHLBI
Title: Heme-induced platelet mtROS drives TSP1 release to accelerate PH pathogenesis
Project timeline: 4/5/2017-1/31/2021
Direct Costs: $1,000,000
Indirect Costs: $559,836

 

PI: Sarah Gaffen, PhD, Division of Rheumatology and Clinical Immunology | Bio
Agency: NIDCR
Title: Host and Fungal Regulation of Type 17 immunity to oral candidiasis
Project timeline: 8/1/2017-7/31/202
Direct Costs: $1,958,165
Indirect Costs: $720,969

 

PI: David G. Binion, MD, Division of Gastroenterology, Hepatology and Nutrition | Bio
Agency: DOD
Title: Utilizing Clinical Metadata to Predict High-Cost Complications and Treatment Response in IBD:  Development of Clinical Decision Support Tools
Project timeline: 9/1/2017-8/31/2020
Direct Costs: $1,752,129
Indirect Costs: $951,399

 

PI: David C. Whitcomb, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition | Bio
Agency: DOD
Title: Mechanism of Systemic Inflammation-Associated Endothelial and Epithelial Cell Dysfunction Following Acute Pancreatitis, Trauma and Burns
Project Timeline: 9/1/2017-8/31/2020
Direct Costs: $1,199,906
Indirect Costs: $649,419

 

PI: Christopher P. O’Donnell, PhD, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Myocardial Infarction and Mechanisms of Impaired Sleep and Breathing
Project Timeline: 4/1/17—3/31/21
Direct Costs: $1,000,000
Indirect Costs: $560,939

 

PI: Yutong Zhao, MD, PhD, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Regulation of Proteolysis by Deubiquiting Enzyme in Lung Inflammatory Disease
Project Timeline: 3/1/17—2/28/21
Direct Costs: $1,000,000
Indirect Costs: $523,483

 

PI: Carolyn Anderson, PhD, Division of Cardiology | Bio
Agency: NCI
Title: Image Guided Immunotherapy and Targeted Radionuclide Therapy of Metastatic Melanoma
Project Timeline: 1/1/17—12/31/21
Direct Costs: $1,487,937
Indirect Costs: $833,982

 

PI: Stephen J. O’Keefe, MD, MSc, Division of Gastroenterology, Hepatology and Nutrition | Bio
Agency: NCI
Title: Randomized Controlled Trial of Resistant Starch to Reduce Colon Cancer in Alaska Native People
Project Timeline: 1/10/17—12/31/21
Direct Costs: $2,055,223
Indirect Costs: $765,068