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Research

The University of Pittsburgh Department of Medicine is a formidable leader in cutting-edge research. Our basic scientists, clinical researchers, and clinicians work daily to make research discoveries that will positively impact the world’s healthcare.

Our numbers:

Our scientists, physician-scientists, and clinicians do the advanced research that is changing people’s lives—and furthering our understanding of science. The papers they publish in high-impact journals … the grants and training awards they receive, including five new T32s in fiscal year 2015-16 … are all reflections of our investigators’ skill, dedication, and commitment.


  • Latest High-Impact Publications
  • Latest Grants, $1 Million and Above
   

Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence.
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE.
JAMA. 2018 May 15;319(19):2021-2031.
PMID: 29800214

 

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.
Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J,  Zhang L.
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3930-3935.
PMID: 29581256

 

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.
Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML4 Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR ,Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV; National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP).
J Clin Invest. 2018 Mar 1;128(3):997-1009
PMID: 29400693

 

Drug Interactions With Non-Vitamin K Oral Anticoagulants.
Linnebur SA, Hanlon JT.
JAMA. 2018 Feb 27;319(8):828-829.
PMID: 29486025

 

Future of nonnucleoside reverse transcriptase inhibitors. 
Sluis-Cremer N.
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):637-638.
PMID: 29326232

 

Lipid metabolic reprogramming in hepatic ischemia-reperfusion injury.
Monga SP.
Nat Med. 2018 Jan 9;24(1):6-7.
PMID: 29315298

 

   

PI: Sonya Borrero, MD, MS, Division of General Internal Medicine | Bio
Agency: NIMHD
Title: Developing and Testing a Decision Support Tool for Women Making Tubal Sterilization Decisions
Project timeline: 8/14/2017 – 4/30/2022
Direct Costs: $2,702,184
Indirect Costs: $847,599

 

PI: Margaret Ragni, MD, MPH, Division of Hematology/Oncology | Bio
Agency: NHLBI
Title: Von Willebrand Disease Minimize Menorrhagia (VWDMin) Trial
Project timeline: 9/1/2017 – 8/31/2022
Direct Costs: $2,425,589
Indirect Costs: $957,442

 

PI: Stephen Y. Chan, MD, PhD, Division of Cardiology | Bio
Agency: NHLBI
Title: Molecular Drivers of Vascular Stiffness and Metabolic Dysfunction in HIV-Induced Pulmonary Arterial Hypertension
Project timeline: 7/1/2017 – 6/30/2021
Direct Costs: $1,874,177
Indirect Costs: $567,690

 

PI: Sally E. Wenzel, MD, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Type-2 or Not Type-2:  That is the (Therapeutic) Question
Project timeline: 9/23/2017 – 6/30/2023
Direct Costs: $1,787,755
Indirect Costs: $587,510

 

PI: James DeLany, PhD, Division of Endocrinology | Bio
Agency: NIDDK
Title: Dynamic PET Imaging in Skeletal Muscle and Adipose Tissue to Explore Mechanisms of Lower Peripheral Glucose Uptake in African American Women
Project timeline: 9/1/2017 - 6/30/2020
Direct Costs: $1,465,546
Indirect Costs: $492,518

 

PI: Sanjay A. Patel, MD, MS, Division of Pulmonary, Allergy and Critical Care | Bio
Agency: George Washington University / NIH
Title: Sleep Reading and CPAP Monitoring Center (SCC) to Support the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Trial of Continuous Positive Airway
Project timeline: 10/1/2017 – 8/31/2024
Direct Costs: $1,443,975
Indirect Costs: $260,980

 

PI: Janet S. Lee, MD, Division of Pulmonary, Allergy and Critical Care | Bio
Agency: NHLBI
Title: Mechanisms of Host Protection Against Pathogen-Secreted Proteases in Acute Lung Injury
Project timeline: 8/1/2017 – 6/30/22
Direct Costs: $1,426,738
Indirect Costs: $797,886

 

PI: Walid Gellad, MD, MPH, Division of General Internal Medicine | Bio
Agency: NIDA
Title: Using Machine Learning to Predict Problematic Prescription Opioid Use and Opioid Overdose
Project timeline: 9/1/2017 – 6/30/2020
Direct Costs: $1,417,843
Indirect Costs: $357,422

 

PI: Alison Morris, MD, MS, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Dysbiosis Impact on Lung Disease in HIV (DimpL) Study
Project timeline: 9/1/2017 – 5/31/2021
Direct Costs: $1,356,431
Indirect Costs: $540,535

 

PI: Ramon Bataller, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition | Bio
Agency: NIAAA
Title: Molecular Subtypes for Targeted THerapies in Alcoholic Hepatitis
Project timeline: 6/21/2017 – 5/31/2018
Direct Costs: $1,106,524
Indirect Costs: $351,734

 

PI: Raju Reddy, MD, Division of Pulmonary, Allergy and Critical Care Medicine | Bio
Agency: NHLBI
Title: Airway epithelial Cell Farnesoid X Receptor in COPD Pathophysiology
Project timeline: 8/1/2017 – 6/30/2021
Direct Costs: $1,000,000
Indirect Costs: $562,709